Selected Publications

Coessentiality and Cofunctionality: A network approach to learning genetic vulnerabilities from cancer cell line fitness screens.  Traver Hart, Clara Koh, Jason Moffat. bioRxiv 134346; doi: https:/doi.org/10.1101/134346. [bioRxiv preprint]

Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens
Traver Hart
, Amy Tong, et al. G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277 [G3]

Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S.  Nat Med. 2017 Jan;23(1):60-68. doi: 10.1038/nm.4219. [Nature Medicine]

BAGEL: a computational framework for identifying essential genes from pooled library screens.
Hart T, Moffat J.  BMC Bioinformatics. 2016 Apr 16;17:164. doi: 10.1186/s12859-016-1015-8. [BMC Bioinformatics] [Sourceforge]

High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities 
Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth P, Rissland OS, Durocher D, Angers S, Moffat J. Cell 2015. doi: 10.1016/j.cell.2015.11.015 [Cell]

  • Related editorial
    The indispensable genome 
    Charles Boone and Brenda J. Andrews   Science 2015. Nov 27;6264(350):1028. Science

 

Measuring Error Rates in Genomic Perturbation Screens: Gold Standards for Human Functional Genomics 
Hart T, Brown KR, Sircoulomb F, Rottapel R, Moffat J. Mol Syst Biol. 2014 Jul 1;10(7):733. doi: 10.15252/msb.20145216 Pubmed

  • Related editorial 
    The Good, The Bad and The Ugly: In Search of Gold Standards for Assessing Functional Genetic Screen Quality 
    Evers B, Bernards R, Beijersbergen RL.   Mol Syst Biol. 2014 Jul 1;10(7):738. doi: 10.15252/msb.20145372 Pubmed

 

Older publications are available on pubmed.